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. 2019 Sep 3;10:946. doi: 10.3389/fphar.2019.00946

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Copyright © 2019 Zhu, Dai, He, Xu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Structure of iron (II) complex, Fe(PIP)₃SO₄. (B) IC₅₀ values of Fe(PIP)₃SO₄ toward glioma cell lines (U87, U251, and C6 cells) and normal cell lines (HEB and CHEM5 cells) after incubation for 72 h. (C) Cellular uptake of Fe(PIP)₃SO₄ in U87 and HEB cells in 8-h treatment. Cells mentioned were incubated with Fe(PIP)₃SO₄ (10 μM) for consecutive time. Values are presented as means ± SD in triplicate. Significant difference between the treatment and control groups is indicated at the P<0.05 (*), P<0.01 (**), or P<0.001 (***) level.