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. 2019 Sep 3;10:946. doi: 10.3389/fphar.2019.00946

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Copyright © 2019 Zhu, Dai, He, Xu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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G2/M phase arrest and apoptotic cell death in U87 cells triggered by Fe(PIP)₃SO₄. Cell cycle analysis of G2/M phase arrest and apoptosis induced by Fe(PIP)₃SO₄ in U87 cells. Cells were exposed to (A) Fe(PIP)₃SO₄ (5, 10, 20, and 40 μM, for 36 h) and (B) Fe(PIP)₃SO₄ (20 μM for 24, 36, 48, and 72 h). (C) Schematic diagram of anticancer mechanism for Fe(PIP)₃SO₄ in U87 cells. (D) Effects of Fe(PIP)₃SO₄ on the expression levels of G2/M phase arrest and apoptotic cell death in cancer cells (treatment time 24 h).