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. 2019 Sep 3;10:946. doi: 10.3389/fphar.2019.00946

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Copyright © 2019 Zhu, Dai, He, Xu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of intracellular ROS levels of U87 cells induced by Fe(PIP)₃SO₄. (A) Intracellular ROS generation in U87 cells after treatment with Fe(PIP)₃SO₄ (5, 10, 20, and 40 μM, respectively) for 120 min. (B) The free radical–scavenging capacity of Fe(PIP)₃SO₄ (5, 10, 20, and 40 μM, respectively) in 120 min was determined by ABTS assay. Values are presented as means ± SD in triplicate. (C) The detection of ROS in U87 cell exposure to Fe(PIP)₃SO₄ in 120 min by fluorescence microscopy, as detected by DCF staining. Scale bar = 200 μm.