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. 2019 Sep 3;10:946. doi: 10.3389/fphar.2019.00946

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Copyright © 2019 Zhu, Dai, He, Xu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Permeability across BBB and inhibition of VM capability induced by Fe(PIP)₃SO₄. (A) Schematic diagram for coculture mimic BBB model. (B) Transmittance ratio of Fe(PIP)₃SO₄ and Fe(IP)₃SO₄ across BBB. (C) Cellular uptake of Fe(PIP)₃SO₄ on U87 cells after penetrating BBB for 24 h. Values are presented as means ± SD in triplicate. The treated concentration for Fe(PIP)₃SO₄ and Fe(IP)₃SO₄ were 10 μM. Values are presented as means ± SD in triplicate. (D) Inhibition of VM capability of U87 cells induced by Fe(PIP)₃SO₄ (2.5, 5, and 10 μM, respectively) for 24 h.