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. 2019 Sep 3;10:946. doi: 10.3389/fphar.2019.00946

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Copyright © 2019 Zhu, Dai, He, Xu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo biodistribution of Fe content in the brains after administration (i.v.). (A) Schematic diagram for the experimental design. (B) In vivo Fe content in the brains after i.v. administration for 24, 48, and 72 h, respectively. The gray histograms were represented for the control group; the pink and blue histograms were represented for Fe content levels in brain treated with Fe(PIP)₃SO₄ (4 and 8 mg/kg, respectively). Values are presented as means ± SD in triplicate. Significant difference between treatment groups was indicated at the P < 0.05 (*) level. (C) Relative penetration ratio across BBB after i.v. administration for 24, 48 and 72 h, respectively. The yellow and green histograms were represented for the Fe content inside the brains treated with Fe(PIP)₃SO₄ (4 and 8 mg/kg, respectively). Values are presented as means ± SD in triplicate. Significant difference between treatment groups is indicated at the P < 0.05 (*) level.