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. 2019 Sep 3;10:946. doi: 10.3389/fphar.2019.00946

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Copyright © 2019 Zhu, Dai, He, Xu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Penetrating capability and inhibitory effects of Fe(PIP)₃SO₄ on U87 tumor spheroids. (A) Schematic diagram for the experimental design. (B) Inhibitory effects of U87 tumor spheroids treated with Fe(PIP)₃SO₄ (20 and 40 μM, respectively) for consecutive days. Significant difference between the treated and control groups is indicated at the P < 0.05 (*) or P < 0.01 (**) level. (C) Penetrating ability for Fe(PIP)₃SO₄ (20 and 40 μM, respectively) into the brain tumor spheroids for 12 h.