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. 2019 Sep 3;10:775. doi: 10.3389/fgene.2019.00775

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Copyright © 2019 Finnegan, Cho, Luu, Harirchian, Lee, Cheng and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Basal keratinocyte network analysis identifies gene and TF modules specific to basal functions. (A) Regulation of four GO-enriched gene modules by TF modules, represented as a directed graph. Gene module nodes show log-transformed stage-wise mean imputed expression normalized across stages 1 to 7 with shading of 1 standard deviation interval. Transcription factor modules list their TF constituents. Arrows indicate regulation with width proportional to predicted strength of activation (red) or inhibition (blue). (B) Minus log of adjusted p values for selected GO terms enriched in each gene module. See also Supplementary File 1: Figure S5 .