Fig. 4.

Improvement in (a) insomnia, (b, c) sleep quality, (d–f) daytime impairment, and (g) quality of life over 14 weeks of therapy by mode.

a. Insomnia Severity Index (ISI)

b. Sleep quality – Likert (SQ-Lik)

c. Sleep quality – percent (SQ-Pct)

d. Insomnia Impairment Index (III)

e. Fatigue Severity Scale (FSS)

f. Functional Outcomes of Sleep Questionnaire Short Form (FOSQ-10)

g. Quality of Life Enjoyment and Satisfaction Questionnaire Summary Form (QLESQ)

Estimated trajectories for primary outcomes of each mode are shown along with 95% confidence intervals for average scores at each time point. Overlap in the band indicates intersection of confidence intervals. (a) Average ISI scores for ASV patients drop below clinical threshold for insomnia (ISI = 8) by week 7 and statistical separation between modes occurred at week 11. (b) Mean SQ-Lik scores were consistently higher for ASV shortly after baseline, with statistically significant separation by the third week. (c) Mean SQ-Pct scores were consistently higher for ASV reaching nearly 80% at final follow-up with significant separation between the modes by the second week. (d) III mirrored the changes in ISI but significant separation between the modes did not occur until week 13. (e–g) No statistical separation between modes occurred, although there was a trend for between mode separation in QLESQ scores.