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Enzalutamide-resistant MDVR cells display increased Wnt signaling. A. GSEA analysis of RNA-sequencing data comparing MDVR to C4-2B demonstrates that MDVR cells display enrichment of Wnt pathway gene sets. B. RNA-sequencing FPKM values were compared and show increased expression of several Wnt pathway targets in MDVR versus C4-2B cells. C. Western blot shows that LRP6 and phospho-LRP6 expression is increased in MDVR cells versus C4-2B cells. GAPDH served as a loading control.
