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A: timeline of selected key events in lysine-specific demethylase (LSD1) research and development in therapeutically targeting LSD1 inhibitors in sickle cell disease (SCD). B: the LSD1 inhibitor RN-1 has 2 distinct mechanisms. One addresses sickle hemoglobin (HbS) polymerization-mediated sickling, and the other addresses red blood cell (RBC) reactive oxygen species (ROS) generation-induced hemolysis. HbF, fetal hemoglobin; Retics, reticulocytes.
