Table 2.
Cardioprotective effects of aerobic exercise in rodent and murine models exposed to ACs
| Author | Animal Species/Age | Anthracycline Dose (mg/kg)/Type | Exercise Protocol | Outcome Parameter |
|---|---|---|---|---|
| Smuder et al. (51) | Rats/6 mo old | 20b/DOX | Treadmill, 60 min/day, 5 consecutive days | Aerobic exercise regulates catalase protein levels and increases removal rate of ROS. |
| Ashrafi and Roshan (4) | Rats/8 wk old | 10 or 20b/DOX | Treadmill, 25–39 min, 5 days/wk, 3 wk | Aerobic exercise upregulates antioxidant defenses. |
| Chicco et al. (9) | Rats/unspecified | 15b/DOX | 20–60 min/day, 5 days/wk, 12 wk | Aerobic exercise attenuates AC-induced myocardial lipid peroxidation. |
| Gibson et al. 2013 (19) | Rats/10 wk old | 15b/DOX | Voluntary wheel running, 14 wk | Aerobic exercise counteracts AC-induced upregulation of autophagy system markers. |
| Hydock et al. (26) | Rats/unspecified | 10b/DOX | Voluntary wheel running or treadmill, 20–60 min/day, 5 days/wk. Both 10 wk | Aerobic exercise preserves β-MHC expression ratio for >10 days. |
| Jensen et al. (28) | Rats/10 to 11 wk old | Bolus: 10b/DOX | Voluntary wheel running, 10 wk, or treadmill, 20–60 min/day, 5 days/wk, 10 wk | Aerobic exercise preserved cardiac function and reduced AC accumulation in LV. |
| Shirinbayan and Roshan (50) | Rats/10 wk old | 10 or 20b/DOX | Treadmill, 25–39 min/day, 5 days/wk, 3 wk | Aerobic exercise associated with increased expression of HSP70. |
| Wonders et al. (61) | Rats/unspecified | Bolus: 15b/DOX | Treadmill, 2 wk acclimation protocol, single acute bout, 60 min | Single acute bout of aerobic exercise preserved LV function via mitigation of AC-induced oxidative stress. |
| Hayward et al. (22) | Rats/25 days old | IP injection: 14c/DOX | Voluntary wheel running, 10 wk | Aerobic exercise preserved function of remaining cardiomyocytes. |
| Sturgeon et al. (54) | Mice/6–8 wk | Bolus: 4c/DOX | Modality not stated, 45 min/day, 5 days/wk, 2 wk | Aerobic exercise upregulates Akt signaling (pathway involved in cellular survival and growth), but no significant cardioprotection. |
| Hydock et al. (25) | Rats/unspecified | Bolus: 15a,c/DOX | Voluntary wheel running, 10 wk | Low intensity and low volume of exercise adequate to provide cardioprotection. |
DOX, doxorubicin; HSP70, 70-kDa heat shock protein; MHC, myosin heavy chain; ROS, reactive oxygen species, IP, intraperitoneal.
a
Exercise intervention before AC treatment;
b
exercise intervention concomitant with AC treatment;
c
exercise intervention after AC treatment.