Fig. 1.

A: structure of the epoxyeicosatrienoic acid (EET) analog N-isopropyl-N-{5-[(2-pivalamidobenzo[d]thiazol-4-yl)oxy]pentyl}heptanamide (EET-B). B: design of the experiments analyzing the cardioprotective action of EET-B in rat hearts. C: design of the experiments analyzing immunoreactivity of hypoxia-inducible factor (HIF)-1α and prolyl hydroxylase domain protein 3 (PHD3) in the ischemic area and nonischemic septum at the end of ischemia and in reperfusion of vehicle- and EET-B-treated rats. See materials and methods for a detailed description. 2-ME, 2-methoxyestradiol; 14,15-EEZE, 14,15-epoxyeicosa-5(Z)-enoic acid; Acri, acriflavine; EET, epoxyeicosatrienoic acid; ISCH, ischemia; REP, reperfusion.