Fig. 4.

Myocardial infarct size expressed as a percentage of the area at risk (A) and relationship between area at risk and infarct size, both expressed as a percentage of the left ventricle (B), in rats administrated vehicle, the epoxyeicosatrienoic acid (EET) analog EET-B (2.5 mg/kg iv) or 14,15-EET (2.5 mg/kg iv) 5 min before reperfusion, or the hypoxia-inducible factor-1α inhibitor 2-methoxyestradiol (2-ME; 0.5 and 2.5 mg/kg iv, respectively) alone or combined with EET-B and 14,15-EET, respectively, 10 min before reperfusion. Values are means ± SE from 5−9 rats. *P < 0.05 vs. vehicle; †P < 0.05 vs. EET-B.