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. 2019 Apr 3;316(5):R640–R650. doi: 10.1152/ajpregu.00320.2018

Fig. 1.

Fig. 1.

Stromal prorenin receptor (PRR) is crucial for normal nephrogenesis. A: image of gel electrophoresis showing target genotypes. B: PRR/GAPDH mRNA levels are reduced in the whole conditional deletion (cKO) compared with control (Con) kidney on postnatal day 0 (P0). C: glomerular number/kidney section is reduced in cKO compared with Con kidney at P0. D: macroscopic views of Con and cKO kidneys at embryonic day 18.5 (E18.5), showing similar kidney size. E–G: hematoxylin and eosin-stained kidney sections. E: at E15.5, the overall structure of a cKO kidney appears similar to the one of the littermate Con. F and G: at P0, cKO kidney shows marked decrease in the thickness of the cortex with reduction in nephron number (braces in F) and delayed nephrogenesis in cKO compared with Con kidneys (G). Arrow in G depicts S-shaped nephron. Scale bar, 1,000 µM.