Table 1.
Blood and urine parameters after ipragliflozin treatment for 8 wk
| 8 Wk |
||||
|---|---|---|---|---|
| Characteristic | Cont+Veh (n = 5) | Cont+Ipra (n = 12) | SDT+Veh (n = 10) | SDT+Ipra (n = 10) |
| Kidney weight, g | 1.84 ± 0.08 | 2.01 ± 0.07 | 2.44 ± 0.11‡ | 2.29 ± 0.08‡ |
| Urinary protein, mg/day | 9.3 ± 1.4 | 9.7 ± 0.9 | 62.0 ± 14.9‡ | 26.5 ± 4.3† |
| Hematocrit, % | 43.8 ± 0.5 | 43.1 ± 0.8 | 45.9 ± 0.5‡ | 46.3 ± 0.3 |
| Serum creatinine, mg/dl | 0.33 ± 0.01 | 0.32 ± 0.01 | 0.31 ± 0.01 | 0.31 ± 0.01 |
| Creatinine clearance, L/day | 7.5 ± 0.6 | 7.5 ± 0.4 | 6.9 ± 0.3 | 7.4 ± 0.4 |
| Electrolyte-free water clearance, mL/day | −28.5 ± 9.9 | −15.8 ± 7.9 | 110.7 ± 8.3‡ | 97.2 ± 8.3‡ |
| Serum Na+, mEq/L | 144 ± 1 | 144 ± 1 | 137 ± 1 | 143 ± 1† |
| Serum Cl−, mEq/L | 102 ± 1 | 103 ± 1 | 94 ± 1 | 102 ± 1† |
| Serum K+, mEq/L | 5.7 ± 0.3 | 5.6 ± 0.1 | 5.0 ± 0.2 | 4.8 ± 0.2 |
| Fractional excretion of glucose, % | 0.2 ± 3.1 | 37.2 ± 2.7* | 37.3 ± 2.8‡ | 63.4 ± 2.8†‡ |
| Fractional excretion of Na+, % | 0.29 ± 0.03 | 0.35 ± 0.03 | 0.65 ± 0.05 | 0.56 ± 0.03 |
| Fractional excretion of Cl−, % | 0.46 ± 0.04 | 0.52 ± 0.04 | 0.95 ± 0.07 | 0.80 ± 0.05† |
| Fractional excretion of K+, % | 14.1 ± 1.0 | 17.1 ± 1.3 | 30.8 ± 1.8 | 30.0 ± 1.7 |
| Fractional excretion of fluid, % | 0.5 ± 0.2 | 0.8 ± 0.2* | 3.4 ± 0.2‡ | 2.9 ± 0.2‡ |
| Serum aldosterone, pg/mL | 272 ± 39 | 299 ± 26 | 260 ± 62 | 239 ± 19 |
| Urinary vasopressin, pg/day | 2,940 ± 1,223 | 3,728 ± 476 | 1,3481 ± 1,429 | 13,601 ± 1,728 |
| Serum osmolality, mosmol/kgH2O | 301 ± 2 | 299 ± 1 | 324 ± 2‡ | 316 ± 2†‡ |
| Urine osmolality, mosmol/kgH2O | 1,589 ± 254 | 1,638 ± 57 | 907 ± 23‡ | 957 ± 49‡ |
Values are means ± SE. Cont+Ipra, SD rats with Ipra; Cont+Veh, SD rats with Veh; Ipra, standard diet containing ipragliflozin (100 mg/kg diet); SD, Sprague-Dawley; SDT, Spontaneously Diabetic Torii; SDT+Ipra, SDT rats with Ipra; SDT+Veh, SDT rats with Veh; Veh, standard diet (CLEA Rodent Diet CE-2).
*
P < 0.05 vs. Cont+Veh;
†
P < 0.05 vs. SDT+Veh;
‡
P < 0.05 vs. Cont same treatment.