A and B: uncoupling protein 2 (Ucp2) protein levels assessed by protein-simple assay in control, doxorubicin (Dox)-, Dox + synthetic humanin analog (HNG)-, Dox + dexrazoxane (DRZ)-, and Dox + HNG + DRZ-treated mice (A) and in control, HNG alone-, and DRZ alone-treated mice (B). HNG + DRZ significantly normalized Ucp2 protein suppressed by Dox to control levels. Values in the bar graph represent means ± SE of the area under the curve of Ucp2 signals normalized by that of the corresponding total proteins.