Table 1.

Studies of deep brain stimulation treatment for anorexia nervosa.

Reference	N	Gender	Age of surgery (years)	Target	Duration of FU (months)	BMI		Comorbidities (type, n, scores at baseline/LFU)
						Baseline	LFU
McGregor et al. 2010	1	Female	52	Subgenual cingulate cortex	3	18.0	19.1	NA
Lipsman et al. 2017	16	Female	34 ± 8	Subcallosal cingulate	12	13.8 ± 1.5	17.3 ± 3.4	OCD: 16, 27.9 ± 8.6/14, 19.7 ± 10.3 a Anxiety: 16, 38.0 ± 15.6/14, 19.7 ± 18.4 b
Blomstedt et al. 2017	1	Female	56	MFB in the posterior hypothalamic area	36	16.2	14.3	Anxiety: 1, 34/1, 15 c Depression:1, 22/1, 13 d
Zhang et al. 2013	4	Female	17 ± 1	NAc	1	12.1 ± 0.8	15.7 ± 1.9	NA
Wang et al. 2013	2	Female	23 ± 5	NAc	12	13.1 ± 0.2	19.4 ± 1.4	OCD: 2, 22 ± 7/2, 14 ± 5 a Anxiety: 2, 29.5 ± 5.5/2, 7.5 ± 0.5 c
Lipsman et al. 2013	6	Female	38 ± 11	Subcallosal cingulate	9	13.7 ± 1.4	16.6 ± 3.2	OCD: 6, 25.0 ± 10.9/6, 13.2 ± 6.9 a Anxiety: 6, 31.2 ± 18.8/6, 21.7 ± 14.1 b Depression: 6, 17.8 ± 8.2/6, 10.7 ± 8.4 d
Wu et al. 2013	4	Female	17 ± 1	NAc	9-50	11.9 ± 1.2	19.6	OCD: 3, 20/3, 1.7 a Anxiety: 1, 19/1, 2 c

N, number of patients; MFB, medial forebrain bundle; NAc, nucleus accumbens; BMI, body mass index; FU, follow-up; LFU, last follow-up.

^aYale–Brown Obsessive Compulsive Scale (Y-BOCS).

^bBeck Anxiety Inventory (BAI).

^cHamilton Rating Scale for Anxiety (HAM-A).

^dHamilton Rating Scale for Depression (HAM-D).