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. 2016 Nov 7;2016(11):CD003668. doi: 10.1002/14651858.CD003668.pub4

Gouna 2013.

Methods DESIGN: randomised cross‐over study
 Method of randomisation: not stated
 Infant’s position: random assignment to the order of positions: supine, prone and lateral left. Body positions were stabilised in a semiflexed posture for infants placed on the left side (tucked position).
 Blinding to intervention: no
 Complete follow‐up: yes
 Blinding to outcome measurement: no
Participants SETTING: neonatal intensive care unit, Lille, France
 DATE OF SAMPLE COLLECTION: over a 6‐month period, year not stated
PARTICIPANTS
  • Sample size analysed: 19 preterm infants on NCPAP

  • Gestational age at birth (weeks) (mean ± SD): 27 ± 2

  • Postnatal age (days) (mean ± SD): 17 ± 5

  • Birth weight (grams) (mean ± SD): 950 ± 150

  • Study weight (grams) (mean ± SD): 1300 ± 275

  • Associated conditions: All infants were treated for mild respiratory failure.

  • Exclusions: circulatory failure, receipt of vasoactive drugs, periventricular leukomalacia or intraventricular haemorrhage

Interventions INTERVENTIONS: left lateral vs supine, prone vs supine, prone vs left lateral position
 
 CO‐INTERVENTIONS: All infants received caffeine treatment.
Outcomes Outcomes of interest in this review: SpO2, FiO2, transcutaneous PCO2, TV in mL/kg (spontaneous breath), apneic episodes; variables recorded 60 to 180 minutes after positioning and during quiet sleep periods only
 
 Outcomes not assessed in this review: phase angle between abdominal and thoracic movements, rib cage contribution to TV and dynamic elevation of end‐expiratory lung volume, heart and respiratory rates, arterial blood pressure
User defined 1  
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method of randomisation not stated
Allocation concealment (selection bias) Unclear risk Method of allocation not stated
Blinding of outcome assessment (detection bias) 
 All outcomes High risk  
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Complete follow‐up
Selective reporting (reporting bias) Unclear risk No prespecified primary outcomes, so unclear
Other bias Low risk