Nakhaee 2015.

Methods	RCT Comparative trial three‐armed trial Cross‐over design
Participants	Pruritus: UP Description: participants with ESRD who were treated with haemodialysis Number of participants randomised: 25 Number of participants evaluable: 23 Avena sativa group: 8 Vinegar solution group: 7 Hydroxyzine group: 8 Withdrawals/dropouts: 2 (vinegar solution group) Reason for dropout: 2 kidney transplantations Age (mean ± SD): 57.04 years ± 12.20 Sex (male/female): 17 (73.9%)/6 (26.1%) Underlying disease(s): ESRD Participant pool: single‐centre Setting: inpatient Haemodialysis (mean ± SD): duration: 3.55 ± 2.78; frequency (per week): 2.57 ± 0.51 Baseline pruritus assessment: yes Duration/severity of pruritus (mean ± SD): 5.19 years ± 4.85 Baseline parameters: Intensity (mean ± SD): vinegar: 5.19 ± 1.88, avena sativa : 5.21 ± 1.69, hydroxyzine: 5.21 ± 1.82 Frequency (mean ± SD): vinegar: 1.95 ± 1.06, avena sativa : 2.30 ± 1.18, hydroxyzine: 2.04 ± 0.92 Surface % (mean ± SD): vinegar: 33.86 ± 24.11, avena sativa : 29.30 ± 23.28, hydroxyzine: 29.83 ± 22.32
Interventions	Intervention 1: avena sativa lotion (Spain), twice daily Intervention 2: vinegar solution (30 mL synthetic white vinegar 5% in 500 mL of water), twice daily Intervention 3: hydroxyzine tablet, 10 mg tablet every night Additional medication: NA Route of administration: intervention 1 and 2: topical; intervention 3: oral Duration of treatment: 2 weeks Follow‐up: no information
Outcomes	Clinical response to treatment: complete response, partial response and no response VAS: a 10 cm long line on which 0 referred to no pruritus and 10 showed the most severe pruritus the patient could imagine Adverse events Additional outcomes: frequency, surface percentage of total body surface, verbal descriptor, consequences
Notes	Washout: 72 hours "All the patients performed the interventions completely."
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Patients were assigned by random numbers to 3 groups
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	High risk	Blinding not possible due to type of interventions
Blinding of outcome assessment (detection bias) All outcomes	High risk	Blinding not possible due to type of interventions
Incomplete outcome data (attrition bias) All outcomes	Low risk	2 kidney transplantations
Selective reporting (reporting bias)	Low risk	No indication
Size of study (possible biases confounded by small size)	High risk	Number of participants randomised: 23
Other bias	Low risk	The study protocol was registered in the Iranian Registry of Clinical Trials (IRCT2013021912525N1); http://www.irct.ir/searchresult.php?id=12525&number=1