Henker 1987.

Methods	Randomized, open‐label, cross‐over study. Duration: each arm was for 4 weeks. No run‐in period specified. Single centre in the former East Germany.
Participants	45 participants with CF. Age: mean 11.8 years. Gender split: 24 boys and 21 girls.
Interventions	Group 1: Pancreon forte (conventional). Group 2: Creon® (acid protected microspheres).
Outcomes	Weight gain, height, stool frequency, FFE.
Notes	Outcomes were given in a descriptive method.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Information not given.
Allocation concealment (selection bias)	Unclear risk	Information not given.
Blinding of participants and personnel (performance bias) Participants	High risk	No blinding.
Blinding of participants and personnel (performance bias) Clinicians	High risk	No blinding.
Blinding of outcome assessment (detection bias) All outcomes	High risk	No blinding.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Information not given.
Selective reporting (reporting bias)	High risk	Narrative results only ‐ could not be included in analysis.
Other bias	Unclear risk	Information not given.