Knill 1973.
| Methods | Randomized double‐blind cross‐over study with 3 arms. Duration: 3 months in total, each arm lasted 1 month, not clear if washout period was used. |
| Participants | 11 adults with CF and 1 adult with chronic pancreatitis. |
| Interventions | Pancrex V Forte: 3 tablets equivalent to 3 g pancreatine BP. Nutrizym: 2 tablets equivalent to 3.2 g pancreatine BP. Nutrizym plus bromelin: 2 tablets equivalent to 3.2 g pancreatine BP also containing 50g bromelin. Nutrizym tablets looked the same whether containing bromelin or not, but not identical to Pancrex V Forte. Participants not allowed to tell outcome assessors how many tablets they were taking. |
| Outcomes | Self‐reported bowel habits, general health and respiratory symptoms (daily diary), FFE. |
| Notes | Combined data given for all participants (CF data not split out). Full study in French ‐ needs translation. 2 participants who had been on high doses of Pancrex V Forte (9 ‐ 12 per meal) took double the normal preparations in the study. |