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. 2016 Nov 23;2016(11):CD008227. doi: 10.1002/14651858.CD008227.pub3

Knill 1973.

Methods Randomized double‐blind cross‐over study with 3 arms.
Duration: 3 months in total, each arm lasted 1 month, not clear if washout period was used.
Participants 11 adults with CF and 1 adult with chronic pancreatitis.
Interventions Pancrex V Forte: 3 tablets equivalent to 3 g pancreatine BP.
Nutrizym: 2 tablets equivalent to 3.2 g pancreatine BP.
Nutrizym plus bromelin: 2 tablets equivalent to 3.2 g pancreatine BP also containing 50g bromelin.
Nutrizym tablets looked the same whether containing bromelin or not, but not identical to Pancrex V Forte. Participants not allowed to tell outcome assessors how many tablets they were taking.
Outcomes Self‐reported bowel habits, general health and respiratory symptoms (daily diary), FFE.
Notes Combined data given for all participants (CF data not split out). Full study in French ‐ needs translation.
2 participants who had been on high doses of Pancrex V Forte (9 ‐ 12 per meal) took double the normal preparations in the study.