Table 1.
Results From a Survey of US Hospital-Based Pharmacists on First-Line Agents for Treatment of CRE Infections
| Type of CRE Infection, Percentage of Respondents (Number) | ||||
|---|---|---|---|---|
| Agent Positioned as First-Linea | Pneumonia | Bacteremia | Intra-abdominal | Urinary Tract |
| Ceftazidime-avibactam | 54% (51/95) | 58% (52/89) | 51% (47/93) | 36% (33/91) |
| Meropenem-vaborbactam | 32% (30/95) | 31% (28/89) | 31% (29/93) | 14% (13/91) |
| Plazomicin | 2% (2/95) | 1% (1/89) | 1% (1/93) | 5% (5/91) |
| Other | 13% (12/95) | 10% (9/89) | 17% (16/93) | 44% (40/91)b |
| Polymyxinc | 4% (4/95) | 4% (4/89) | 4% (4/93) | 3% (3/91) |
| Aminoglycosided | 2% (2/95) | 1% (1/89) | 2% (2/93) | 11% (10/91) |
| Tigecyclined | 2% (2/95) | 0 | 5% (5/93) | 3% (3/91) |
| Fosfomycin | 0 | 0 | 0 | 15% (14/95) |
| Nitrofurantoin | 0 | 0 | 0 | 5% (5/91) |
| Trimethoprim/sulfamethoxazole | 0 | 0 | 0 | 3% (3/91) |
| Miscellaneous | 3% (3/95)e | 2% (2/89)f | 3% (3/93)g | 7% (6/91)h |
| Not specifiedi | 1% (1/95) | 2% (2/89) | 2% (2/93) | 2% (2/91) |
Abbreviations: CRE, carbapenem-resistant Enterobacteriaceae.
aFor each type of CRE infection, survey participants selected the agent positioned as first-line against CRE infections at their hospital from a multiple-choice menu that included ceftazidime-avibactam, meropenem-vaborbactam, plazomicin, or “other”; a single choice was permitted. If other was chosen, participants could enter specific agents as free text.
bThe sum of “other” responses is 49 since survey participants could list more than 1 agent.
cIncludes polymyxins ± carbapenem.
dNot specified if administered as monotherapy or in combination.
eIncludes the following agents that were listed once each: aztreonam, minocycline, ceftolozane-tazobactam.
fIncludes the following agents that were listed once each: aztreonam, ceftolozane-tazobactam.
gIncludes the following agents that were listed once each: aztreonam, minocycline, ceftolozane-tazobactam.
hIncludes the following agents that were listed once each: minocycline, ceftolozane-tazobactam, cefepime, double carbapenems, levofloxacin, chlorpactin irrigation.
i“Not specified” indicates that no agent was listed, or the respondent stated that agents were selected based on susceptibility data without naming an agent.