Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A loss-of-function FTO mutant increases the repressive effect on its own promoter. (A) EMSA showing an increased binding of the mutant FTO-I367F to its own promoter. (B) Luciferase assays showing that the mutant FTO-I367F increased the repressive effect on its own promoter. n = 10, *P < 0.001. (C) Luciferase assays showing that Fe2+ increased the mutant binding to its own promoter. n = 3, *P < 0.001.
