Fig. 7.

Tertiary amines metabolic profile From left to right, in the first column there is the list of drug metabolizing enzymes, one for each row; in the second, third, fourth, fifth and sixth columns relationship between corresponding enzyme of the row and different Tricyclic: is indicated by the symbol ‘S’ for substrate, ‘Inh’ for inhibitor and ‘Ind’ for inducer. Enzymes CYP2C19 and 2D6 are rimmed to emphasize their importance in these tertiary amines’ metabolic destiny. Related page at the website http://bioinformatics.charite.de/transformer