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. 2019 Sep 10;19:237. doi: 10.1186/s12935-019-0945-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Transcriptional activity correlates with TFIIH levels. a Sections of testis (Xpb^y/y mouse) showing seminiferous tubules were stained with either anti-GFP or anti-HA (DNA content as counter staining). In both images, TFIIH concentration (via XPB) follows the known peripheral-to-central reduction of transcriptional activity. Mature sperm cells in the lumen of the tubules only appear in counter staining (no detectable TFIIH). Scale bars 50 µm. b Plots of the total amount of mRNA versus the total quantity of XPB (green), p62 (blue), TBP (yellow) and RNAP2 (red), per nucleus (in arbitrary units) for Mouse Dermal Fibroblasts. N = 111; 72; 119 and 94, respectively. c Plot of the corresponding Spearman correlation coefficient between mRNA and XPB, p62, TBP and RNAP2 levels. RNAP2 and mRNA levels do not appear correlated