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. 2019 Sep 9;20:192. doi: 10.1186/s13059-019-1802-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Footprint symmetry analysis reveals the primary and secondary motifs. a Symmetry analysis calculates the ascent and descent rates for the two sides of footprint via fitting an exponential decay curve to each part. b An example of exponential decay curve that is fit on real data. c A perfect symmetry indicates a primary motif (HGATAA). d A substantial difference between ascent and descent rates would indicate a motif footprint with an asymmetric footprint shape, as shown by CMCDCCC, MGGAAR, and RTGASTCA secondary motifs. Asymmetry is quantified by the footprint symmetry score (FSS)