Table 3.
Radiation target volumes | Radiation dose | Boost / Elective fields | Chemotherapy | |
---|---|---|---|---|
NSCLC trial | Primary lung tumour and involved regional lymph nodes | 66 Gy in 24 fractions | N.A. | Cisplatin 6 mg/m2 1.5–2 h before radiation on every radiotherapy day# |
Breast cancer trial | Whole breast and involved regional lymph node areas | 46.69 Gy in 23 fractions | SIB of 14.49 Gy in 23 fractions to macroscopic tumour in breast; sequential boost of 10 Gy in 5 fractions to macroscopic lymph nodes (only if applicable) | N.A. |
HNSCC trial | Primary tumour and regional metastatic lymph nodes; elective lymph node volumes based on site of primary tumour and stage | 70 Gy in 35 fractions | Elective fields: 46 Gy in 23 fractions (sequential boost technique) or 54.25 Gy in 35 fractions (SIB technique) | N.A. |
# in the CCRT arm only. Gy = Gray. N.A. = not applicable, SIB = simultaneous integrated boost