Table 1.

Summary of key findings

	Relative Alkalosis (2DG)	Extrinsic Acidosis	Intrinsic Acidosis (SLC-0111)	Intrinsic Acidosis (Hypoxia)	CA IX K/O
Extracelluar pH	↑	↓	↓	↓	↑
Intracelluar pH
CA IX	↓	↓	↓		↓
NHE1
Metabolism	↓	↓	↑	↑	↓
Migration		↓	↓		↓
Network formation	↓	↑
N-cadherin	↑

Up arrow indicates an increase, down arrow indicates a decrease in each variable. 2DG, 2-deoxy-d-glucose; CA, carbonic anhydrase; K/O, knockout; NHE-1, Na⁺/H⁺ exchanger 1.