Experimental design. Dams were placed on diet for 8 wk before breeding and remained on diet through pregnancy and lactation (maternal diet). Pups were euthanized at PN0, PN7, and PN21. Weaned pups were placed on postnatal CD or HFD and euthanized at PN90 (adult diet). CD, control diet; HFD, high-fat diet; PFT, pulmonary function test; PN, postnatal day.