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. 2019 Sep 10;20:704. doi: 10.1186/s12864-019-6039-9

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — a) Proportion of hyper-methylation vs. hypo-methylation among age-associated CpGs (p < 5 x 10^− 8) by genomic region, stratified by sex. b) Log2 odds ratio using the median unbiased estimate and the mid-p exact 95% confidence interval were used to compare women to men by genomic region in aggregate table format. All Fisher exact tests comparing the proportiontion of hyper-methylation (vs. hypo-methylation) within individual categories to "all regions" were significant among either men or women with all p < 4.5 x 10^− 8. For Fisher exact tests comparing the proportion of hyper-methylation (vs. hypomethlylation) between men and women within each category, only shore and open sea where significant with p = 0.0001 and 0.0342, respectively