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. 2019 Sep 10;20:704. doi: 10.1186/s12864-019-6039-9

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Proportion of CpGs residing in genomic regions defined by CpG density. All but the red bar represents age-associated CpGs. Fisher exact tests comparing enrichment/depletion within individual categories to all categories were significant (p < 2 x 10^-11) among men for island, shelf, and open sea regions and among women for all four categories (p = 3.8 x 10^-5). Fisher exact tests comparing enrichment/depletion within categories between men and women were significant for island (p = 0.0071) and shore (p = 0.0015) regions