Fig. 5.

a) Proportion of hyper-methylated and hypo-methylated CpGs among age-associated CpGs (p < 5 x 10^− 8) by relationship to gene category, stratified by sex. b) Log2 odds ratio using the median unbiased estimate and mid-p exact 95% confidence interval were used to compare women to men within each category in aggregate table format. Fisher exact tests comparing the proportion of hyper-methylation (vs. hypo-methylation) within individual categories to all categories were significant among men for TSS200 (p = 0.0001), first exon (p = 7.3 x 10^-11), and body (p = 0.0001) regions and among women for TSS1500 (p = 1.2 x 10^-11), TSS200 (p = 1.6 x 10^-9), first exon (p = 2.2 x 10^-16), and body (p = 0.0034) regions. For Fisher exact tests comparing hyper-methylation between men and women within each category, only body (p = 0.0125) was significant