Table 5.

Response to OnabotA. Statistical analysis

FAMILY	GENE	SNP	p
			CHANGE	ANALYSIS BY PHENOTYPE	ALLELE FREQUENCY	ALLELE VARIANT RECESIVITY HYPOTHESIS	ALLELE VARIANT DOMINANCE HYPOTHESIS
Genes related to glutamate homeostasis	MEF2D	rs1050316	G > T	0.907	0.729	0.836	0.665
	LRP1	rs11172113	T > C	0.583	0.439	0.963	0.319
	MTDH	rs1835740	A > G	0.596	0.740	0.527	0.543
	EAAT2	rs4354668	T > G	0.266	0.105	0.147	0.231
	GRIK3	rs6691840	A > C	0.218	0.176	0.088	0.397
CGRP	CALCA	rs3781719	T > C	0.023	0.029	0.794	0.007
		rs145837941	A > G	–	–	–	–
GABA Receptor system	GABRE	rs1139916	A > C	0.312	0.522	0.977	0.148
	GABRQ	rs3810651	A > T	0.824	0.532	0.619	0.604
	GABRA3	rs6627221	T > C	0.271	0.190	0.977	0.074
		rs2201169	T > C	0.381	0.195	0.436	0.205
Voltage dependent channels	SCN9A	rs6746030	G > A	0.400	0.603	0.367	0.419
	KCNS1	rs734784	A > G	0.615	0.458	0.854	0.333
	P2RX7	rs2230912	A > G	0.972	0.863	0.950	0.837
		rs1718119	C > T	0.628	0.584	0.351	0.916
Dopamine receptor	DRD2	rs1800497	C > T	0.775	0.699	0.773	0.569
Serotoninergic receptor	HTR2C	rs3813929	C > T	0.332	0.163	0.675	0.139
TRPfamily	TRPV1	rs222749	G > A	0.040	0.021	0.013	0.102
		rs222747	G > C	0.749	0.740	0.459	0.958
		rs222741	C > T	0.922	0.777	0.843	0.698
	TRPV3	rs7217270	A > G	0.553	0.275	0.446	0.317
	TRPM8	rs10166942	T > C	0.656	0.655	0.361	0.873
Others	WFS1	rs734312	G > A	0.767	0.655	0.498	0.989
	TGFBR2	rs7640543	G > A	0.925	0.920	0.729	0.929
	MTHFR	rs121434294	C > T	–	–	–	–