Table 1.
Clinical Characteristics and Oxytocin Parameters of the Study Participants (n = 67)
| Variables | All Participants |
|---|---|
| Age, y | 22.4 ± 0.9 |
| BMI z score (<20 y, n = 28) | −1.3 ± 0.1 |
| BMI (≥20 y, n = 39), kg/m2 | 17.9 ± 0.2 |
| Expected body weight, % | 85.4 ± 1.3 |
| Restricting/binge-purge behavior, n (%) | 53 (79)/14 (21) |
| Premenarchal, n (%) | 3 (4.5) |
| Lower estrogen status, n (%)a | 43 (64.2) |
| Higher estrogen status, n (%) | 24 (35.8) |
| Kilocalories consumed | 376.9 ± 9.9 |
| EDE global score | 3.0 ± 0.2 |
| Oxytocin parameters | |
| OT T0, pg/mL | 1024.6 ± 55.4 |
| OT T30 pg/mL | 999.6 ± 51.0 |
| Difference in OT from T0 to T30, pg/mL | −24.9 ± 28.4 |
| OT T60, pg/mL | 919.5 ± 45.8 |
| Difference in OT from T0 to T60 (pg/mL) | −105.1 ± 32.6 (0.002)b |
| OT T120, pg/mL | 940.2 ± 48.7 |
| Difference in OT from T0 to T120 (pg/mL) | −84.4 ± 28.9 (0.005)b |
| OT nadir, pg/mL | 820.4 ± 42.6 |
| Difference in OT from T0 to nadir (pg/mL) | −204.3 ± 24.7 (<0.001)b |
| Change in OT from T0 to nadir, % | −17.8 ± 1.9 |
Data are reported as mean ± SEM.
Abbreviations: T0, time 0 (fasting); T30, time 30 min following the meal; T60, time 60 min following the meal; T120, time 120 min following the meal.
a
Lower estrogen status includes females who are in the early to mid-follicular phase of the menstrual cycle, amenorrheic, or premenarcheal.
b
P value compared with baseline oxytocin (paired t test).