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The overall least-squares (LS) mean change in the Migraine-Specific Quality of Life Questionnaire role function-restrictive domain (MSQ-RFR) is shown for patients with LFEM and HFEM receiving placebo, 120-mg, or 240-mg of galcanezumab in the upper row. The monthly LS mean changes in MSQ-RFR for patients receiving these treatments is shown in the bottom row for patients with LFEM and with HFEM. ***p ≤ .001, **p ≤ .01, *p ≤ .05 vs placebo
