Table 5.

Plasma neurosteroid levels in the overall population of patients affected by chronic migraine during the headache attack and in the interictal period

	Chronic migraine during attack (n = 27)	Chronic migraine no attack (n = 24)	Controls
AP (ng/mL)	1.1 ± 0.4*	1.1 ± 0.2*	0.6 ± 0.3
EAP (ng/mL)	0.5 ± 0.1	0.4 ± 0.2	0.4 ± 0.1
DHEA (ng/mL)	1.4 ± 0.9*	1.8 ± 1.2*	5.1 ± 3.8
DHEAS (μg/mL)	1.5 ± 1.1*	1.0 ± 0.6*	2.7 ± 2.0

Values are means + S.D. *p<0.05 vs. the respective control groups. No significant changes were found between values obtained during the attack and in the interictal period. Statistical analysis was performed by One-way ANOVA + Fisher’s LSD (AP, F_2,79 = 24.79; EAP, F_2,79 = 1.43; DHEA, F_2,79 = 18.06; DHEAS, F_2,79 = 10.66)