Table 1.
Characteristics of studies included in the systematic review*†
| Author, year (reference) | Country | n | Age (years) | Male (%) | Follow-up (months) | Hypertension (%) | DM (%) | CAD (%) | AAD type | Admission CRP (mg/L) | CRP cut-off (mg/L) | Hospital mortality (%) | Mid-term mortality (%) | Adjusted effect estimate | Study design | Confounders |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Schillinger, 2002 (8) |
Austria |
255 |
69 |
70 |
19 |
46 |
10 |
29 |
A/B |
13 (5-63) |
13.0 |
- |
47 |
HR 2.20 (1.10-4.40) |
prospective |
Age, gender, hemodynamic shock, mechanical ventilation, CAD, aortic rupture, DM, hemoglobin, surgery |
| AlMahameed, 2010 (15) |
USA |
115 |
72 |
54 |
36 |
81 |
17 |
44 |
A/B |
21 (5-109) |
20.0 |
4.3 |
25 |
Hospital mortality:
OR 1.34 (0.65-2.73)
Mid-term
mortality:
OR 1.57 (1.13-2.18) |
retrospective |
Age, gender, AAD type, white blood cell count |
| Wen, 2013 (16) |
China |
114 |
49 |
84 |
length of hospital stay |
81 |
28 |
NR |
A/B |
14 vs 11‡ |
11.2 |
27 |
- |
OR 2.32 (1.13-4.76) |
prospective |
AAD type, smoking, blood pressure, aortic diameter, time to admission, D-dimer, surgery |
| Vrsalovic, 2015 (17) |
Croatia |
54 |
69 |
63 |
length of hospital stay |
93 |
9 |
NR |
A |
9 (4-17) |
9.8 |
44 |
- |
OR 7.00 (1.30-37.30) |
retrospective |
Age, gender, surgery, troponin, time to admission |
| Mori, 2016 (18) | Japan | 173 | 67 | 61 | 36 | 64 | 8 | 2 | A/B | 4 vs 2‡ | 16.0 | - | 8 | HR 2.70 (1.20-5.50) | retrospective | Age, gender, surgery, history of aortic aneurysm, D-dimer |
*AAD – acute aortic dissection; CAD – coronary artery disease; CRP – C-reactive protein; DM – diabetes mellitus; HR – hazard ratio; NR – not reported; OR – odds ratio.
†Continuous variables are reported as mean or median (interquartile range).
‡Non-survivors vs survivors.