Skip to main content
. 2019 Aug;60(4):361–368. doi: 10.3325/cmj.2019.60.361

Table 2.

Leading single nucleotide polymorphisms (SNPs) associated with non-alcoholic fatty liver disease (NAFLD) identified by the allelic association test. The adjusted odds ratio (OR) and confidence interval (CI) were obtained in logistic regression analysis with an additive genetic model adjusting for age, sex, and body mass index

Chromosome SNP ID Position Gene Wild/alternative allele P (unadjusted) P (Bonferroni correction) FDR-BH* Adjusted OR (95% CI)
11
rs2303861
44618466
CD82
A/G
2.49 × 10−7
0.0059
0.0059
9.07 (1.92-42.81)
4
rs13116873
26362678
RBPJ
C/G
2.12 × 10−6
0.0502
0.0181
13.91 (2.38-81.45)
2
rs4671501
63404754
WDPCP
A/C
3.69 × 10−6
0.0875
0.0181
0.10 (0.02-0.58)
14
rs1742546
91417155
CCDC88C
G/A
4.15 × 10−6
0.0984
0.0181
0.25 (0.10-0.61)
19
rs2075754
41871176
RPS19
T/C
4.39 × 10−6
0.1043
0.0181
4.96 (1.57-15.66)
10
rs3752752
71695444
CDH23
T/C
4.57 × 10−6
0.1085
0.0181
4.52 (1.71-11.92)
7 rs740949 148808972 EZH2 A/G 8.37 × 10−6 0.1987 0.0284 0.19 (0.06-0.57)

*False discovery rate obtained by Benjamini-Hochberg method.