Table 3.
Association between significant single nucleotide polymorphisms (SNPs) and clinical and biochemical variables in non-alcoholic fatty liver disease (NAFLD) patients and controls. Coefficients (B) and their standard errors (SE) and P values were obtained from multiple linear regression analysis adjusted for age, sex, and body mass index
| SNP |
Subject |
Aspartate aminotransferase |
Alanine aminotransferase |
Fasting blood glucose |
Triacylglycerols |
Low-density lipoprotein |
High-density lipoprotein |
Systolic blood pressure |
Diastolic blood pressure |
Waist circumference |
Hip circumference |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B (SE) |
P |
B (SE) |
P |
B (SE) |
P |
B (SE) |
P |
B (SE) |
P |
B (SE) |
P |
B (SE) |
P |
B (SE) |
P |
B (SE) |
P |
B (SE) |
P |
||
| rs2303861 |
Control |
0.09 (3.89) |
0.982 |
-1.71 (2.51) |
0.502 |
-1.89 (3.82) |
0.625 |
-2.22 (22.78) |
0.923 |
-2.99 (8.18) |
0.718 |
2.28 (3.00) |
0.454 |
12.80(4.88) |
0.015 |
1.90(2.22) |
0.401 |
3.15 (2.31) |
0.185 |
-0.48(1.55) |
0.761 |
| NAFLD |
-2.63 (2.82) |
0.362 |
-2.76 (3.69) |
0.463 |
-2.15 (8.52) |
0.803 |
-7.94 (16.76) |
0.64 |
-6.14 (7.07) |
0.395 |
0.78 (1.90) |
0.687 |
1.97 (3.17) |
0.542 |
0.52 (1.87) |
0.782 |
-1.12 (3.06) |
0.716 |
-1.07 (3.05) |
0.729 |
|
| rs13116873 |
Control |
7.37 (8.55) |
0.397 |
10.78 (5.20) |
0.049 |
-0.64 (8.58) |
0.941 |
17.39 (50.81) |
0.735 |
-2.86 (18.33) |
0.877 |
-0.80 (6.78) |
0.907 |
21.55 (11.60) |
0.076 |
2.41 (5.03) |
0.636 |
-6.58 (5.19) |
0.218 |
-5.86 (3.25) |
0.084 |
| NAFLD |
0.16 (3.18) |
0.96 |
2.08 (4.11) |
0.618 |
17.28 (8.71) |
0.06 |
5.06 (18.63) |
0.788 |
3.01 (7.94) |
0.709 |
1.39 (2.09) |
0.512 |
4.45 (3.42) |
0.206 |
2.35 (2.02) |
0.256 |
4.49 (3.26) |
0.182 |
5.17 (3.20) |
0.12 |
|
| rs4671501 |
Control |
-0.09 (2.32) |
0.971 |
-2.00 (2.93) |
0.505 |
0.94 (3.78) |
0.808 |
-4.01 (17.37) |
0.817 |
-8.75 (7.15) |
0.241 |
0.44 (3.42) |
0.899 |
11.66 (5.99) |
0.072 |
3.59 (2.65) |
0.197 |
3.42 (2.05) |
0.117 |
1.43 (1.45) |
0.338 |
| NAFLD |
-10.33 (14.69) |
0.49 |
-26.23 (18.44) |
0.171 |
-60.50 (41.90) |
0.165 |
-75.54 (86.53) |
0.394 |
-62.85 (35.00) |
0.088 |
22.68 (7.87) |
0.01 |
-6.05 (16.48) |
0.718 |
-1.08 (9.66) |
0.912 |
6.53 (8.40) |
0.447 |
-2.91 (4.97) |
0.566 |
|
| rs1742546 |
Control |
-15.89 (4.27) |
0.003 |
-6.04 (3.56) |
0.118 |
-3.88 (4.90) |
0.446 |
54.14 (27.09) |
0.071 |
-22.89 (8.47) |
0.021 |
-1.48 (3.66) |
0.695 |
3.05 (7.21) |
0.68 |
-1.51 (2.66) |
0.581 |
-5.47 (2.38) |
0.042 |
0.90 (1.72) |
0.612 |
| NAFLD |
-1.73 (3.43) |
0.622 |
-3.51 (4.15) |
0.413 |
-19.42 (12.12) |
0.133 |
-9.93 (24.47) |
0.692 |
-7.70 (10.42) |
0.473 |
1.47 (3.01) |
0.634 |
-4.66 (3.59) |
0.217 |
-2.27 (2.19) |
0.319 |
7.50 (4.21) |
0.098 |
-8.24 (4.23) |
0.073 |
|
| rs2075754 |
Control |
-6.94 (5.16) |
0.208 |
-6.38 (6.42) |
0.344 |
11.28 (7.94) |
0.186 |
80.10 (31.87) |
0.031 |
11.31 (13.70) |
0.429 |
-3.25 (6.59) |
0.633 |
-15.23 (9.35) |
0.135 |
-10.00 (4.19) |
0.038 |
-0.173 (5.90) |
0.977 |
-2.28 (3.82) |
0.564 |
| NAFLD |
-2.65 (2.34) |
0.281 |
-1.41 (4.48) |
0.759 |
-1.64 (5.29) |
0.762 |
-10.54 (16.29) |
0.531 |
-16.28 (6.36) |
0.027 |
-3.20 (1.48) |
0.053 |
4.04 (4.60) |
0.399 |
2.80 (2.49) |
0.286 |
2.51 (2.15) |
0.267 |
1.42 (1.02) |
0.192 |
|
| rs3752752 |
Control |
-1.93 (5.82) |
0.746 |
0.67 (2.19) |
0.766 |
2.56 (4.07) |
0.541 |
-12.42 (29.84) |
0.684 |
-8.50 (10.86) |
0.448 |
7.85 (3.56) |
0.046 |
-0.40 (5.88) |
0.946 |
1.02 (1.87) |
0.594 |
2.44 (3.18) |
0.457 |
-0.811 (1.83) |
0.665 |
| NAFLD |
-2.69 (3.72) |
0.48 |
-4.10 (4.13) |
0.335 |
-1.75 (11.09) |
0.876 |
18.09 (22.93) |
0.442 |
11.74 (7.90) |
0.157 |
1.24 (2.25) |
0.589 |
-0.21 (4.33) |
0.962 |
1.41 (2.59) |
0.595 |
0.54 (4.33) |
0.903 |
-1.50 (4.14) |
0.722 |
|
| rs740949 | Control |
1.13 (4.11) |
0.786 |
0.91 (2.84) |
0.753 |
0.82 (3.33) |
0.81 |
0.07 (23.93) |
0.998 |
-9.37 (7.61) |
0.237 |
-0.35 (3.30) |
0.917 |
0.28 (6.29) |
0.965 |
1.97 (2.38) |
0.421 |
0.11 (2.51) |
0.965 |
1.73 (1.62) |
0.302 |
| NAFLD | 1.16 (4.23) | 0.789 | 4.42 (7.78) | 0.581 | 21.80 (16.93) | 0.222 | 65.19 (37.44) | 0.107 | -22.96 (14.77) | 0.146 | -3.78 (3.85) | 0.345 | -2.35 (5.44) | 0.673 | -3.95 (2.88) | 0.195 | 0.77 (2.23) | 0.735 | -0.42 (2.04) | 0.841 | |