Table 1.

Cohort characteristics

Patient	Sex	Age	Tumour	Location	Histology	Grade	MSI	TNM	T size (cm)	Adenomas
s894	M	79	s894–1	Descendens	ac	2	MSS	T2N0M0	6	Yes
			s894–2	Descendens	ac in situ	2	MSS	Tis	1.2
c440	M	83	c440–1	Border of rectosigma	ac in situ	1	MSS	Tis	NA	Yes
			c440–2	Caecum	ac	3	MSI	T3N0M0	4.5
sync_1	M	82	sync_1–1	Caecum	ac	3	MSS	T2N0M0	3.5	No
			sync_1–2	Transversum	ac	3	MSS	T3N0M0	5
sync_2	M	82	sync_2–1	Rectum	ac	2	MSS	T4N0M1	4.3	Yes
			sync_2–2	Rectum	ac in situ	1	MSS	Tis	NA
sync_3	F	67	sync_3–1	Rectum	ac	2	MSS	T3N1M0	NA	Yes
			sync_3–2	Rectum	ac	2	MSS	T1	NA
s75	M	71	s75–1	Rectum	ac muc	3	MSS	T3N0M0	4	Yes
			s75–2	Caecum	ac	2	MSS	T3N0M0	5
s1268	M	66	s1268–1	Ascendens	MANEC	4	MSS	T3N2M0	5.2	Yes
			s1268–2	Sigma	ac	2	MSS	T3N1M1	4
s882	F	67	s882–1	Rectum	ac	2	MSS	T1	1	No
			s882–2	Caecum	ac	2	MSS	T4N0M0	2
sync_4	M	78	sync_4–1	Ascendens	ac muc	3	MSI	T3N0M0	11	Yes
			sync_4–2	Ascendens	ac muc	3	MSI	T3N0M0	8
s387	M	62	s387–1	Flexura lienalis	ac	1	MSS	T3N1M1	3.5	NA
			s387–2	Flexura lienalis	ac	1	MSS	T3N1M1	8
sync_6	M	72	sync_6–1	Caecum	ac	2	MSS	T4N1M0	4.1	Yes
			sync_6–2	Ascendens	ac	2	MSS	T2N0M0	4.7
s483	F	81	s483–1	Caecum	ac muc	3	MSI	T3N2M0	9	Yes
			s483–2	Ascendens	ac	1	MSI	T1	1.5
s956	M	76	s956–1	Rectum	ac	2	MSS	T3N1M0	6	Yes
			s956–2	Sigma	ac	2	MSS	T3N1M0	4
s404	M	61	s404–1	Sigma	ac	2	MSS	T1N1M0	3.4	Yes
			s404–2	Sigma	ac	2	MSS	T2N1M0	5.5
sync_7	M	72	sync_7–1	Rectum	ac	2	MSS	T2N0M0	4	Yes
			sync_7–2	Sigma	ac	2	MSS	T1	4
sync_9	M	80	sync_9–1	Rectum	ac	2	MSS	T2N0M0	3	Yes
			sync_9–2	Sigma	ac	2	MSS	T1	NA
sync_10	M	59	sync_10–1	Rectum	ac	2	MSS	T3N1M0	4	No
			sync_10–2	Sigma	ac	2	MSS	T4N1M0	4.5
sync_11	M	48	sync_11–1	Ascendens	ac	2	MSI	T3N0M0	3.8	Yes
			sync_11–2	Ascendens	ac	2	MSI	T3N0M0	11
			sync_11–3	Ascendens	ac	2	MSI	T1N0M0	1
s1036	M	77	s1036–1	Sigma	ac	2	MSS	T4N0M0	12	Yes
			s1036–2	Sigma	ac	2	MSS	T1N0M0	1.7
s1283	F	75	s1283–1	Caecum	ac	2	MSI	T3N0M0	3.5	Yes
			s1283–2	Sigma	ac	NA	MSS	T4N2M0	2.5
c110	M	49	c110–1	Rectum	ac	2	MSS	T3N0M0	5	Yes
			c110–2	Descendens	ac	2	MSS	T3N0M0	3.2
c117	F	83	c117–1	Descendens	ac	2	MSS	T3N1M0	7.5	Yes
			c117–2	Rectum	ac	2	MSS	T3N0M0	5
s934	M	51	s934–1	Rectum	ac	2	MSS	T2N0M0	4	No
			s934–2	Sigma	ac	2	MSS	T3N2M0	5

MSI microsatellite unstable, MSS microsatellite stable, ac adenocarcinoma, MANEC mixed adenoneuroendocrine carcinoma, ac muc adenocarcinoma mucinosum, NA not available