Tumour diffusion coefficient after time 0, D
1
|
0 |
Tumour growth rate, λ1
|
1.4 × 10−7 s−1
|
Drug killing rate of tumour, k
1
|
67.9 cm3 µg−1 h−1
|
Initial size of tumour at point source, N
0
|
1.19 × 106 cells |
Time to grow from point source to presentation, t
0
|
4.26 × 107 s |
Tumour diffusion coefficient before time 0, D
0
|
1.5 × 10−8 cm2 s−1
|
Drug killing rate of normal cells, k
2
|
1.27 × 10−3 cm3µg−1 h−1
|
Cell density, θ |
2.04 × 107 cells cm−3
|
Tumour convection constant, a
1
|
267.2 |
Tissue convection constant, a
2
|
1.3 × 10−5 cm3 cells−1
|
Drug loss rate, µ |
8.35 × 10−4 s−1
|
Infusion rate, q
|
6 µL min−1
|
Time duration of infusion, T
|
96 h |
Concentration of injected fluid, c
0
|
9 µg cm−3
|
Clonogenic fraction of tumour cells, f
1
|
1.19 × 10−7
|
Toxic fraction of normal cells, f
2
|
0.01 |
Radius for calculating toxicity, R̂ |
5 cm |