Table 1.

Parameter values for the model

Parameter	Estimate
Tumour diffusion coefficient after time 0, D 1	0
Tumour growth rate, λ1	1.4 × 10−7 s−1
Drug killing rate of tumour, k 1	67.9 cm3 µg−1 h−1
Initial size of tumour at point source, N 0	1.19 × 106 cells
Time to grow from point source to presentation, t 0	4.26 × 107 s
Tumour diffusion coefficient before time 0, D 0	1.5 × 10−8 cm2 s−1
Drug killing rate of normal cells, k 2	1.27 × 10−3 cm3µg−1 h−1
Cell density, θ	2.04 × 107 cells cm−3
Tumour convection constant, a 1	267.2
Tissue convection constant, a 2	1.3 × 10−5 cm3 cells−1
Drug loss rate, µ	8.35 × 10−4 s−1
Infusion rate, q	6 µL min−1
Time duration of infusion, T	96 h
Concentration of injected fluid, c 0	9 µg cm−3
Clonogenic fraction of tumour cells, f 1	1.19 × 10−7
Toxic fraction of normal cells, f 2	0.01
Radius for calculating toxicity, R̂	5 cm