Clinical utility of Children's Hospital of Philadelphia (CHOP) Fusion panel in 276 clinical cases. A: Fusion-positive cases in different cancer groups: leukemia, non–central nervous system (CNS) solid tumors, and CNS tumors. B: Fusion-positive cases in different sample types: bone marrow/blood, fresh/frozen tissue, and formalin-fixed, paraffin-embedded (FFPE) samples. C: Distribution of recurrent and novel fusions detected by CHOP Fusion panel. D: Most abundant recurrent fusions detected in leukemia, non-CNS tumors, and CNS tumors. E: Clinical significance of all fusions detected. VUS, variant of uncertain significance.