Table 2.
Analysis results for the myelokathexis (MK), cyclical (CN) and severe congenital (SCN) neutropenic patients of this study. The fraction f a of apoptotic cells was determined as before. f N , the fraction of circulating neutrophils relative to normal was based on the neutrophil count determined for each individual and a value of 4.4 × 10 3 cells/mm 3 for normal individuals ( Dancey et al. 1976 ). The fraction fT of the post‐mitotic marrow neutrophil precursor compartment (metamyelocytes and bands) was determined from actual bone marrow differentials on each patient and a normal value of 0.445 was determined from a weighted average of the figures of Dancey et al. (1976 ) (Table III, 43.2% of the total marrow neutrophilic cells were metamyelocytes and bands, n = 13) and the control values of Chatta et al. (1996 ) (Table 2, the post‐mitotic pool constitutes 46.0% of total marrow neutrophils, n = 13). The duration of the post‐mitotic compartment τ m was taken to be 1.2 days from Hearn et al. (1998 ) for neutropenic patients. All else as in Table 1
Diag. | f a | f N | f T | γ | δ | V 0 |
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---|---|---|---|---|---|---|---|
MK | 0.10 | 0.089 | 1.02 | 4.85 | 43.6 | 23 | 298.1 |
CN | 0.23 | 0.172 | 0.494 | 3.6 | 11.9 | 7.9 | 52.4 |
SCN | 0.11 | 0.044 | 0.135 | 3.56 | 28.8 | 2.4 | 62.8 |
SCN | 0.10 | 0.014 | 0.045 | 3.61 | 32.4 | 0.83 | 67.6 |