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. Author manuscript; available in PMC: 2019 Sep 10.

Published in final edited form as: Lancet Respir Med. 2016 Jan 21;4(2):107–115. doi: 10.1016/S2213-2600(15)00545-7

Figure 2. — Ivacaftor C_min distribution (A) and ivacaftor AUC distribution (B) in children aged 2–5 years compared with adults from previous Phase 3 studies.

Dashed black lines in the center of the boxes are medians, boxes are the interquartile range (IQR), whiskers are 1·5•IQR, and open circles are outliers.

AUC, area under the plasma drug concentration-vs-time curve; C_min, minimum plasma drug concentration.

Figure 2. — Ivacaftor C_min distribution (A) and ivacaftor AUC distribution (B) in children aged 2–5 years compared with adults from previous Phase 3 studies.

Dashed black lines in the center of the boxes are medians, boxes are the interquartile range (IQR), whiskers are 1·5•IQR, and open circles are outliers.

AUC, area under the plasma drug concentration-vs-time curve; C_min, minimum plasma drug concentration.