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. Author manuscript; available in PMC: 2020 Aug 14.
Published in final edited form as: J Am Chem Soc. 2019 Aug 2;141(32):12558–12569. doi: 10.1021/jacs.9b01253

Figure 8.

Figure 8.

Kinetic isotope effect (kH/kD) determined upon monitoring the rate of reactivity via UV–vis spectroscopy of F8Cmpd-II(LutH+) and F8Cmpd-II(LutD+) toward various concentrations of DHA under pseudo-first-order conditions. Each data point is an average of three trials, and error bars represent the standard deviation. F8Cmpd-II(LutD+) reacted 1.5× faster, indicating both HAA and subsequent protonation are part of the rate-determining step.81