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. 2019 Sep 3;10:2089. doi: 10.3389/fimmu.2019.02089

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Copyright © 2019 Ji, Jian, Chen, Luo, Li, Dai, Bai, Ding, Bi, Wen, Zhou, Abi, Liu and Bao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polyfunctional M72-specific CD4⁺ T-cell evaluation. (A) Forest plot: a SMD > 0 indicates that vaccine can effectively stimulate the growth of polyfunctional CD4⁺ T-cells. SMD = 0, invalid result. Point estimates and 95%CI are shown for each study and for the pooled results. (B) Influence analysis, examine the impact of a study on the total combined effect. The vertical solid line in the middle indicates the total combined effect, while the left and right vertical solid lines indicate 95%CI. (C) Funnel plot: the publication bias was independently assessed by determining the symmetrical distribution of the studies.