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. 2019 Sep 3;10:2029. doi: 10.3389/fmicb.2019.02029

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Copyright © 2019 Ma, He, Yu, Cai, Zeng, Cai, Lu, Chen, Chen and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-kill curves for polymyxin B (PMB) and ceftazidime/avibactam (CZA) monotherapy and combination therapy against polymyxin B-susceptible K. pneumoniae ATCC 700603, and polymyxin B-heteroresistant K. pneumoniae (B1, D1, and D4). (A,E,I,M) PMB (0.5, 1, and 2 mg/L) as monotherapy; (B,F,J,N) PMB (0.5, 1 and 2 mg/L) in combination with CZA (0.25 × MIC); (C,G,K,O) PMB (0.5, 1 and 2 mg/L) in combination with CZA (0.5 × MIC); (D,H,L,P) PMB (0.5, 1 and 2 mg/L) in combination with CZA (1 × MIC). The limit of quantification is indicated by black dashed horizontal lines.