Table 3.

The inhibitory activities of synthesized compounds towards two 5α-reductaseiozymes.

Compound	Type 1 (pH 6.6)		Type 2 (pH 5.5)
	Inh% (1 μM)	IC50 (μM)	Inh% (1μM)	IC50 (μM)
7a	24.96 ± 9.68	–	24.16 ± 1.13	–
7b	52.20 ± 12.33	–	49.91 ± 3.08	–
7c	27.92 ± 4.01	–	24.52 ± 8.47	–
7d	66.42 ± 4.37	0.58 ± 0.06	69.03 ± 9.30	0.41 ± 0.03
7e	54.70 ± 5.94	–	45.75 ± 9.86	–
8a	31.14 ± 6.49	–	19.88 ± 12.91	–
8b	35.76 ± 9.58	–	21.17 ± 1.31	–
8c	25.82 ± 4.22	–	18.29 ± 4.61	–
8d	24.82 ± 9.02	–	26.06 ± 10.34	–
8e	34.09 ± 10.05	–	20.94 ± 10.06	–
9a	53.15 ± 9.71	–	48.69 ± 3.08	–
9b	59.25 ± 2.28	0.63 ± 0.14	49.62 ± 5.75	1.01 ± 0.06
9c	68.02 ± 11.96	0.52 ± 0.06	63.56 ± 12.47	0.41 ± 0.14
9d	80.14 ± 6.73	0.09 ± 0.02	71.92 ± 3.40	0.08 ± 0.07
9e	70.77 ± 9.74	0.23 ± 0.09	79.41 ± 2.47	0.21 ± 0.09
Finasteride	73.69 ± 4.22	1.04 ± 0.08	70.04 ± 4.12	0.04 ± 0.02