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. 2019 Aug 12;9(20):5769–5783. doi: 10.7150/thno.36505

Figure 7.

Figure 7

Corylin Decreases the Atherosclerosis Development in ApoE-/- Mice. Six-week-old male ApoE-/- mice were randomly grouped (n=12) and fed with WD supplemented with vehicle (0.5% CMC-Na), corylin (30mg/kg) or lovastatin (30 mg/kg) for 16 weeks. After the treatment, the mice were sacrificed and subjected to various analyses as described below. (A) Food intake during the 16 weeks experiment period. (B) Body weight of each group during the 16 weeks experiment period. (C) Representative photographs of plasma from each group. (D) The levels of TC, TG, LDL-c and HDL-c in plasma after 16 weeks treatment. (E) Representative photographs from en face analysis of aortas from different groups after 16 weeks treatment. (F-I) Quantification of the lesion areas in (E). (J) qRT-PCR analysis of gene expression in ApoE-/- mice liver after 16 weeks. For each group, equal amounts of total RNA from three mice were subjected to qRT-PCR quantification. Error bars are represented as mean±SEM. Statistical analyses were done with two-way ANOVA (Bonferroni's test) (A and B) or one-way ANOVA (Dunnett's post test) (D, and F-J). *p < 0.05, **p < 0.01, ***p < 0.001 vs WD.