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Representative in vivo fluorescence imaging of bilateral 4T1 tumor-bearing mice at the time points of 2 h, 8 h, and 24 h post-intravenous injection of PpIX-NLG@Lipo, the prone position view (A) and side-lying position view (B). The ex vivo fluorescence imaging (C) and mean fluorescence intensity (MFI) values (D) of the major organs and tumors at 24 h post-injection. (E) PpIX-NLG concentration of plasma of healthy rats after I.V. injection of PpIX-NLG@Lipo or free PpIX-NLG.
